Table 2.

Cold allodynia phenotype of ion channel KO and cell ablated mice. The symbol ‘↓’ denotes reduced or absent cold allodynia, ‘↑’ denotes enhanced cold allodynia and ‘–’ denotes unchanged cold allodynia in different mouse models of neuropathic pain following genetic manipulation of ion channels and sensory neuron subsets.

Mouse Line			Disease Model
Type	Channels (s)	Manipulation	Complete Freud’s Adjuvant	Chronic Constriction Injury	Oxaliplatin	Ciguatera
Trp	Trpm8	KO	↓(Colburn et al., 2007, Knowlton et al., 2013)	↓(Colburn et al., 2007, Knowlton et al., 2013)	↓(Descoeur et al., 2011), –(Deuis et al., 2013)	–(Vetter et al., 2012)
		DTR	↓(Knowlton et al., 2013)
	Trpa1	KO			↓(Nassini et al., 2011), –(Deuis et al., 2013)	↓(Vetter et al., 2012)
K2P	TRAAK	KO		– (Noël et al., 2009)
	TREK1	KO		↓(Alloui et al., 2006)
	TRAAK/TREK1	Double KO		↑(Noël et al., 2009)	↓(Descoeur et al., 2011)
	TREK2	KO			↓(Pereira et al., 2014)
	TRAAK/TREK1/TREK2	Triple KO			↓(Pereira et al., 2014)
	TRESK	KO			↓(Castellanos et al., 2019)
NaV	NaV1.7	Avil-Cre KO		↓(Minett et al., 2014a, Minett et al., 2014b, Minett et al., 2012)	–(Minett et al., 2014a, Minett et al., 2014b)
		Wnt1-Cre KO		↓(Minett et al., 2014a, Minett et al., 2014b)	–(Minett et al., 2014a, Minett et al., 2014b)
	NaV1.8	KO		↓(Leo et al., 2010, Minett et al., 2014a, Minett et al., 2014b)	–(Deuis et al., 2013, Minett et al., 2014a, Minett et al., 2014b)	↓(Vetter et al., 2012)
		DTA			–(Minett et al., 2014a, Minett et al., 2014b)	↓(Vetter et al., 2012)
	NaV1.9	KO		↓(Leo et al., 2010, Minett et al., 2014a, Minett et al., 2014b)	↓(Lolignier et al., 2015), –(Deuis et al., 2013, Minett et al., 2014a, Minett et al., 2014b)	–(Vetter et al., 2012)