Table 2.
Risk of death during 60 days of follow-up at six sites (The Gambia, Mali, Mozambique, India, Bangladesh, and Pakistan)
| Number of deaths/total*(%) | HR (95% CI) | p value | |
|---|---|---|---|
| GEMS MSD study | |||
| Cases | 138†/7178 (1·9%) | 8·89 (5·55–14·22) | <0·0001 |
| Controls | 26†/10 548 (0·3%) | 1 (ref) | .. |
| GEMS MSD study | |||
| Dysenteric cases | 19†/1952 (1·0%) | 0·41 (0·25–0·67) | 0·0003 |
| Non-dysenteric cases | 119†/5226 (2·3%) | 1 (ref) | .. |
| GEMS-1A MSD study | |||
| Cases | 23/2212 (1·0%) | 11·91 (3·50–40·53) | <0·0001 |
| Controls | 3/3433 (0·1%) | 1 (ref) | .. |
| GEMS-1A LSD study | |||
| Cases | 12‡/2962 (0·4%) | 2·78 (0·95–8·11) | 0·061 |
| Controls | 7/4074 (0·2%) | 1 (ref) | .. |
| GEMS-1A MSD study | |||
| Dysenteric cases | 2/691 (0·3%) | 0·20 (0·05–0·87) | 0·032 |
| Non-dysenteric cases | 21/1521 (1·4%) | 1 (ref) | .. |
| Intra-GEMS-1A comparison of MSD versus LSD | |||
| GEMS-1A MSD study cases | 23/2212 (1·0%) | 2·57 (1·28–5·17) | 0·0080 |
| GEMS-1A LSD study cases | 12‡/2962 (0·4%) | 1 (ref) | .. |
| Intra-GEMS-1A comparison of LSD versus non-dysenteric MSD | |||
| GEMS-1A LSD study cases | 12‡/2962 (0·4%) | 0·29 (0·14–0·59) | 0·0006 |
| GEMS-1A MSD study non-dysenteric cases | 21/1521 (1·4%) | 1 (ref) | .. |
HR=hazard ratio. MSD=moderate-to-severe diarrhoea. LSD=less-severe diarrhoea.
*
The number of participants with follow-up information and therefore for whom health status (deceased or not) was known.
†
These numbers exclude GEMS MSD data from Kenya.
‡
The 12 deaths in children with LSD include five (41·6%) girls and seven (58·3%) boys, paralleling the sex distribution of enrolled LSD cases (1492 [47·0%] girls, 1682 [53·0%] boys).