Table 4. In Vivo Pharmacokinetic Parameters of Compound 11 in Male Rats.

Parametera	I.V.b (5 mg/kg)	P.O.c (5 mg/kg)
Tmax (h)	N/A	1.58 ± 2.1
Cmax (μg/mL)	N/A	0.94 + 0.23
T1/2 (h)	6.67 ± 3.99	3.44 ± 0.37
AUClast (μg·h/mL)	6.3 ± 1.76	5.05 ± 2.37
AUC, (μg·h/mL)	6.42 ± 1.7	5.09 ± 2.39
CL (L/h/kg)	0.81 + 0.2	N/A
Vss (L/kg)	2.95 ± 1.01	N/A
Ft (%)	N/A	80.19

^aEach value is presented as mean ± standard deviation of at least three independent experiments.

^bParameters from intravenous administration.

^cParameters from oral administration.