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. 2020 Jan 27;11(2):188–194. doi: 10.1021/acsmedchemlett.9b00578

Scheme 1. Typical Synthetic Route Utilized for Biphenylbutanoic Acid Derivatives.

Scheme 1

Reagents and conditions: (a) EtI, NaHCO3, DMF, rt; (b) 3-Cl-C6H4-B(OH)2, Pd(PPh3)4, aq. Na2CO3, DME, 95 °C; (c) 4 M HCl in 1,4-dioxane; (d) succinic anhydride, DIPEA, DCM; (e) 1 M aq. NaOH, THF, MeOH, rt; 1 M aq. HCl.