Table 1. Impact of Linker Length on NEP Inhibitory Activitya.
| Compound | R1 | hNEP IC50 (nM) |
|---|---|---|
| 1 (LBQ657) | CH(CH3)COOH (R) | 6 |
| 2 | CH2COOH | 550 |
| 3 | C(CH3)2COOH | 20 |
| 4 | COOH | 25 |
a
IC50 values are the mean of at least two independent assays.
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