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. 2020 Jan 27;11(2):188–194. doi: 10.1021/acsmedchemlett.9b00578

Table 3. Testing SAR of S1′ Substitution in Pentanoic Acid Seriesa.

graphic file with name ml9b00578_0009.jpg

Compound R1 R2 hNEPIC50 (nM)
LBQ657 (R)-CH3 H 6
29 (S)-CH3 Cl 2
30 (R)-CH3 Cl 0.3
31 rac-CH3 Cl 0.8
a

IC50 values are the mean of at least two independent assays.