Table 4. Pharmacokinetic Parameters of 13 and 26 in Sprague Dawley Rat Dosed at 1 mg/kg IV (Parent Compound) and 3 mg/kg PO (Ethyl Ester Prodrug)^a.

Administered Compound	Route	oral Cmax (nM)	AUC(0–7) (nM·Hours)	CL (mL/min/kg)	Vdss (L/kg)	Elimination t1/2 (IV) (Hours)	%F
13 (active)	IV		8730	5	0.1	0.8
36 (prodrug)	PO	12600	10100				42
26 (active)	IV		8100	5	0.1	1.0
39 (prodrug)	PO	5380	5630				25

^a36 is the ethyl ester prodrug of 13; 39 is the ethyl ester prodrug of 26.