. 2020 Jan 29;11(2):203–209. doi: 10.1021/acsmedchemlett.9b00536

Table 2. Toxicity Odds Using 3D-PSA with ClogP (10 μM C_max (Total) Threshold)^a.

Toxicity Odds at 10 μM	3D-PSA ≥ 75	3D-PSA < 75
ClogP < 3	0.24 (57)	1.29 (16)
ClogP ≥ 3	1.02 (91)	1.73 (30)

Kinase inhibitors are excluded.

Table 2. Toxicity Odds Using 3D-PSA with ClogP (10 μM Cmax (Total) Threshold)a.