. 2020 Jan 29;11(2):203–209. doi: 10.1021/acsmedchemlett.9b00536

Table 3. Toxicity Odds Using Measured logD with TPSA (10 μM C_max (Total) Threshold)^a.

Toxicity Odds at 10 μM	TPSA ≥ 75	TPSA < 75
LogD < 2.5	0.67 (60)	0.93 (29)
LogD ≥ 2.5	0.73 (64)	1.27 (34)

Kinase inhibitors are excluded.

Table 3. Toxicity Odds Using Measured logD with TPSA (10 μM Cmax (Total) Threshold)a.