Table 5.
TMS responses and motor parameters before and after lumbar puncture
| Pre-LP mean ± SD | Post-LP mean ± SD | p-value | |
|---|---|---|---|
| Upper limb SP (ms) | 55.5 ± 17.4 | 54.1 ± 20.1 | 0.227 |
| Upper limb RMT (%-MSO) | 26.4 ± 4.3 | 26.1 ± 3.9 | 0.462 |
| Upper limb EF (V/m) | 82.1 ± 13.0 | 83.9 ± 16.0 | 0.601 |
| Lower limb RMT (%-MSO) | 42.2 ± 7.6 | 43.1 ± 8.3 | 0.146 |
| Lower limb EF (V/m) | 149.3 ± 44.2 | 139.2 ± 34.8 | 0.586 |
| IO-max (mV) | 4.8 ± 2.7 | 4.9 ± 2.8 | 0.959 |
| IO-50 (%) | 35.8 ± 5.7 | 36.4 ± 4.9 | 0.642 |
| IO-slope | 2.6 ± 1.2 | 3.1 ± 1.4 | 0.049* |
| TSG (score) | 53.7 ± 25.0 | 58.0 ± 25.2 | 0.039* |
| Gait velocity (m/s) | 0.86 ± 0.27 | 0.95 ± 0.25 | 0.002* |
| Steps (number) | 23.1 ± 6.7 | 21.7 ± 4.9 | 0.017* |
| BBT (pcs) | 54.5 ± 12.5 | 54.6 ± 10.2 | 0.634 |
| GPT (s) | 142.3 ± 105.2 | 125.2 ± 54.0 | 0.705 |
| Balance (score) | 62.5 ± 12.4 | 66.1 ± 4.0 | 0.141 |
n = 18
SP silent period, RMT resting motor threshold, EF electric field, IO-max the maximum value of the input–output curve, IO-50 the mid-point of the input–output curve, IO-slope the slope of the input–output curve, TSG total score of gait, BBT Box and Block Test, GPT Grooved Pegboard Test, Pre-LP before lumbar puncture, Post-LP after lumbar puncture
* Significant differences (p < 0.05) have been indicated (Wilcoxon signed-rank test)