Table 2.
Summary of laboratory data
| Characteristic | n | OFI (N = 394) | n | All dengue patients (N = 1117) | n | Uncomplicated dengue (N = 836) | n | Intermediate dengue (N = 243) | n | Severe dengue (N = 38) |
|---|---|---|---|---|---|---|---|---|---|---|
| At enrollment | ||||||||||
| CRP (mg/L) | 394 | 31.3 (10.2, 88.8) | 1117 | 30.2 (12.4, 61.5) | 836 | 28.6 (10.5, 58.9) | 243 | 35.3 (17.9, 71.8) | 38 | 26.2 (14.1, 71.1) |
| Viremia level (× 106 copies/mL) | – | – | 1050 | 35.5 (3.1, 269.6) | 783 | 25.2 (2.0, 185.4) | 231 | 92.9 (7.5, 690.5) | 36 | 128.5 (33.1, 331.2) |
| AST (UI/L) | 394 | 30.0 (23.0, 40.0) | 1109 | 43.0 (30.0, 67.0) | 831 | 42.0 (30.0, 62.0) | 240 | 52.0 (33.0, 92.2) | 38 | 60.0 (43.0, 84.8) |
| ALT (UI/L) | 394 | 18.0 (13.0, 30.0) | 1113 | 28.0 (18.0, 49.0) | 834 | 27.0 (17.0, 46.0) | 241 | 32.0 (21.0, 67.0) | 38 | 29.0 (18.2, 41.2) |
| Albumin (g/L) | 394 | 45.5 (43.5, 47.5) | 1105 | 45.0 (42.5, 47.1) | 828 | 45.0 (42.7, 47.3) | 239 | 44.3 (41.9, 46.9) | 38 | 44.9 (42.6, 47.3) |
| Creatine kinase (UI/L) | 394 | 92.5 (70.2, 129.0) | 1012 | 105.0 (77.8, 156.2) | 763 | 104.0 (76.0, 149.0) | 221 | 115.0 (83.0, 171.0) | 28 | 138.0 (91.0, 270.0) |
| WBC (× 109/mL) | 394 | 7.7 (5.5, 10.8) | 1113 | 4.3 (3.2, 6.0) | 834 | 4.3 (3.2, 6.0) | 241 | 4.4 (3.1, 6.0) | 38 | 4.0 (2.8, 4.9) |
| Neutrophils (%) | 394 | 71.0 (61.5, 79.0) | 1108 | 67.5 (58.0, 75.2) | 830 | 66.3 (57.0, 74.8) | 240 | 70.0 (61.4, 78.0) | 38 | 72.8 (60.3, 77.9) |
| Lymphocytes (%) | 394 | 16.5 (11.5, 24.1) | 1109 | 18.6 (11.8, 26.9) | 831 | 18.9 (12.4, 27.4) | 240 | 16.9 (10.9, 24.4) | 38 | 19.8 (11.8, 31.3) |
| Other time points | ||||||||||
| Max HCT change* (%) | 360 | 2.4 (− 1.5, 5.8) | 1112 | 7.1 (2.4, 13.7) | 832 | 5.4 (1.7, 9.9) | 243 | 20.5 (8.6, 24.5) | 37 | 16.7 (6.1, 28.2) |
| Platelet nadir (× 109/mL) | 383 | 178 (143, 225) | 1113 | 72.0 (40.0, 119.0) | 834 | 89 (52, 127) | 242 | 40.5 (22.0, 71.0) | 37 | 18 (13, 30) |
| CRP at follow-up (mg/L) | 30 | 1.4 (0.5, 4.1) | 896 | 0.8 (0.4, 2.0) | 668 | 0.8 (0.3, 2.0) | 196 | 0.8 (0.4, 2.0) | 32 | 0.8 (0.5, 2.2) |
Summary statistics are median (interquartile range)
ALT alanine aminotransferase, AST aspartate aminotransferase, CRP C-reactive protein, DOI day of illness, HCT hematocrit, OFI other febrile illnesses, WBC white blood cell
*Maximum HCT change was calculated by maximum HCT level at the acute phase (DOI 4 to 7) minus baseline HCT, then divided by baseline HCT. Baseline HCT was the minimum HCT level within DOI 1 to 3