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. 2020 Feb 7;11:172. doi: 10.3389/fimmu.2020.00172

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Copyright © 2020 Wu, Zhao, Xie, Xu and Fei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of melatonin or luzindole on OVA-induced airway inflammation. (A) Protocol of administration of melatonin or luzindole during establishing allergic airway diseases model. (B,C) Protein expression of TLR2 in lung tissues of OVA-challenged WT mice treated with melatonin or not. (D) Lung histopathology based on H&E staining to evaluate inflammatory cell infiltration, arrows indicates infiltrated leukocytes. (E) Mucus secretion was analyzed based on PAS staining, arrow heads indicates goblet cells. (F) Histological scoring of lung inflammation. (G) Quantification of mucus secretion. *p < 0.05, **p < 0.01, ***p < 0.001.