Table 1.
The role of miRISC proteins in neurodevelopment.
| Differentiation | Migration | Neurite development | Synapse development and synaptic plasticity |
|---|---|---|---|
|
AGO2 (Patranabis and Bhattacharyya, 2016, 2018) FMRP (Castren et al., 2005; Tervonen et al., 2009; Callan et al., 2010; Saffary and Xie, 2011; Jeon et al., 2014) TRIM-32 (Brat, mei-P26,NHL-2) (Bello, 2006; Betschinger et al., 2006; Lee et al., 2006; Bowman et al., 2008; Neumüller et al., 2008; Hammell et al., 2009; Schwamborn et al., 2009; Loewen et al., 2018) Hu Proteins (Marusich et al., 1994; Dobashi et al., 1998; Kasashima et al., 1999; Anderson et al., 2000; Akamatsu et al., 2002, 2005; Perrone-Bizzozero and Bolognani, 2002; Kraushar et al., 2014) Pumilio (Burow et al., 2015; Zahr et al., 2018) ESCRT Factors (Mochida et al., 2012) DDX6 (Nicklas et al., 2015) RBM4 (Tarn et al., 2016; Su et al., 2017) CCR4-NOT (Koch et al., 2014) IPO-8 (Nganou et al., 2018) Hsp-90 (Quintá et al., 2010) |
FMRP (La Fata et al., 2014) IPO-8 (Nganou et al., 2018) RBM4 (Dhananjaya et al., 2018) |
FMRP (Dockendorff et al., 2002; Ivanco and Greenough, 2002; Morales et al., 2002; Michel, 2004; Pan et al., 2004; Li, 2009; Doll and Broadie, 2015; Wang et al., 2015; Zimmer et al., 2017; Shen et al., 2019) MOV10 (Skariah et al., 2017) Pumilio (Menon et al., 2004, 2009; Ye et al., 2004; Vessey et al., 2010; Olesnicky et al., 2012) ESCRT Factors (Sweeney et al., 2006; Konopacki et al., 2016) HPat (Pradhan et al., 2012) hnRNP Q (Chen et al., 2012) IPO-8 (Nganou et al., 2018) Hsp-90 (Quintá et al., 2010; Benitez et al., 2014) |
AGO2 (Rajgor et al., 2017, 2018; Paradis-Isler and Boehm, 2018) GW182 (Rajgor et al., 2018) MOV10 (Ashraf et al., 2006; Banerjee et al., 2009; Kute et al., 2019) FMRP (Jin et al., 2004; Michel, 2004; Pan et al., 2004; Muddashetty et al., 2011; Sudhakaran et al., 2014; Dear et al., 2017; Doll et al., 2017; Wang et al., 2018) CNOT7 (McFleder et al., 2017) Hpat (Pradhan et al., 2012) Pumilio (Menon et al., 2004) |
Several miRISC proteins are known to play an important role during different stages of neuronal development. For some proteins (e.g., AGO2, GW182, FMRP, MOV10), this role is shown to be mediated via miRISC modulation. In others, the potential role of miRISC interaction in regulating neurodevelopment is not understood.