Table 2C.
Selected risk loci (p ≤ 1E-05) for SNP-smoking interactions in combined sample.
| rsID | CHR | POS | A1Ψ | A2 | BETA Nonsmokers | SE Nonsmokers | Allele Freq Nonsmokers | BETA Smokers | SE Smokers | AlleleFreq Smokers | Z_GxE* | P_GXE | Funcrefgene | Generefgene |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs6685095 | 1 | 6502548 | T | C | −0,005 | 0,006 | 0,131 | 0,047 | 0,010 | 0,135 | −4,519 | 6,23E-06 | intronic | ESPN |
| rs11588151 | 1 | 55487648 | G | A | −0,024 | 0,008 | 0,087 | 0,040 | 0,012 | 0,083 | −4,518 | 6,22E-06 | intergenic | BSND,PCSK9 |
| rs74115213 | 1 | 115054290 | G | T | −0,012 | 0,007 | 0,081 | 0,051 | 0,012 | 0,095 | −4,439 | 9,02E-06 | upstream | TRIM33 |
| rs1192824 | 2 | 101821934 | T | C | 0,012 | 0,005 | 0,674 | −0,039 | 0,007 | 0,698 | 5,820 | 5,90E-09 | intergenic | TBC1D8,CNOT11 |
| rs73047627 | 2 | 189842214 | A | G | 0,018 | 0,009 | 0,062 | −0,057 | 0,014 | 0,058 | 4,597 | 4,27E-06 | intronic | COL3A1 |
| rs11695675 | 2 | 200607333 | A | G | −0,022 | 0,006 | 0,155 | 0,033 | 0,009 | 0,167 | −5,095 | 3,48E-07 | intergenic | LOC101927641,FTCDNL1 |
| rs12465362 | 2 | 230587448 | T | G | 0,010 | 0,005 | 0,226 | −0,033 | 0,008 | 0,238 | 4,475 | 7,63E-06 | intergenic | DNER,TRIP12 |
| rs7619102 | 3 | 12728045 | A | G | 0,017 | 0,006 | 0,150 | −0,034 | 0,010 | 0,135 | 4,474 | 7,65E-06 | intergenic | RAF1,TMEM40 |
| rs869784 | 3 | 24348008 | C | T | 0,010 | 0,005 | 0,715 | −0,029 | 0,007 | 0,698 | 4,507 | 6,57E-06 | intronic | THRB |
| rs9834968 | 3 | 69552204 | G | A | 0,019 | 0,008 | 0,086 | −0,044 | 0,012 | 0,082 | 4,481 | 7,45E-06 | intergenic | FRMD4B,MITF |
| rs782444 | 3 | 127409941 | C | T | 0,009 | 0,004 | 0,473 | −0,027 | 0,007 | 0,473 | 4,596 | 4,32E-06 | UTR3 | MGLL |
| rs76169119 | 4 | 40556609 | G | C | 0,022 | 0,009 | 0,063 | −0,055 | 0,014 | 0,058 | 4,658 | 3,20E-06 | intronic | RBM47 |
| rs77655815 | 5 | 107952834 | A | T | −0,016 | 0,008 | 0,056 | 0,068 | 0,015 | 0,068 | −4,882 | 1,06E-06 | intergenic | FBXL17,LINC01023 |
| rs10454990 | 5 | 148838117 | T | C | 0,025 | 0,006 | 0,138 | −0,029 | 0,010 | 0,129 | 4,558 | 5,17E-06 | intergenic | MIR143HG,CSNK1A1 |
| rs62435247 | 6 | 169725827 | G | A | 0,014 | 0,004 | 0,393 | −0,024 | 0,007 | 0,387 | 4,726 | 2,30E-06 | intergenic | THBS2,WDR27 |
| rs62475193 | 7 | 154476372 | A | G | −0,009 | 0,008 | 0,072 | 0,062 | 0,012 | 0,076 | −4,792 | 1,65E-06 | intronic | DPP6 |
| rs16900766 | 8 | 126649041 | G | A | −0,006 | 0,005 | 0,273 | 0,033 | 0,007 | 0,283 | −4,458 | 8,30E-06 | intergenic | TRIB1,LINC00861 |
| rs74509340 | 10 | 480774 | C | T | 0,018 | 0,009 | 0,059 | −0,065 | 0,014 | 0,066 | 4,936 | 7,97E-07 | intronic | DIP2C |
| rs1854462 | 10 | 91991941 | C | T | −0,016 | 0,007 | 0,102 | 0,042 | 0,011 | 0,103 | −4,418 | 9,95E-06 | intergenic | LINC01375,LOC101926942 |
| rs112148169 | 10 | 133210477 | A | T | −0,013 | 0,008 | 0,075 | 0,057 | 0,013 | 0,076 | −4,518 | 6,26E-06 | intergenic | TCERG1L,LINC01164 |
| rs1939309 | 11 | 100421331 | T | C | 0,011 | 0,005 | 0,731 | −0,032 | 0,008 | 0,740 | 4,681 | 2,84E-06 | intergenic | CNTN5,ARHGAP42 |
| rs7492237 | 13 | 84258581 | T | C | 0,015 | 0,005 | 0,263 | −0,029 | 0,008 | 0,270 | 4,962 | 7,01E-07 | intergenic | NONE,SLITRK1 |
| rs1546993 | 14 | 40153203 | A | G | 0,013 | 0,004 | 0,512 | −0,026 | 0,007 | 0,495 | 4,758 | 1,96E-06 | intergenic | FBXO33,LOC644919 |
| rs60889063 | 16 | 54371831 | G | A | 0,011 | 0,005 | 0,233 | −0,032 | 0,008 | 0,235 | 4,593 | 4,39E-06 | intergenic | IRX3,CRNDE |
| rs934166 | 16 | 84631300 | G | A | −0,005 | 0,004 | 0,482 | 0,030 | 0,006 | 0,477 | −4,581 | 4,63E-06 | intronic | COTL1 |
| rs11653290 | 17 | 6983529 | C | A | −0,019 | 0,007 | 0,078 | 0,047 | 0,012 | 0,096 | −4,599 | 4,22E-06 | UTR5 | CLEC10A |
| 17:21509395 | 17 | 21509395 | T | C | −0,015 | 0,008 | 0,090 | 0,049 | 0,012 | 0,086 | −4,537 | 5,73E-06 | intergenic | C17orf51,FAM27L |
| rs8067970 | 17 | 35145662 | A | G | 0,021 | 0,008 | 0,100 | −0,042 | 0,011 | 0,092 | 4,638 | 3,52E-06 | intergenic | MRM1,LHX1 |
| rs10401037 | 17 | 52235347 | G | C | 0,007 | 0,005 | 0,261 | −0,035 | 0,008 | 0,223 | 4,625 | 3,76E-06 | intergenic | KIF2B,TOM1L1 |
| rs4791039 | 17 | 64787600 | A | G | −0,013 | 0,005 | 0,351 | 0,027 | 0,007 | 0,335 | −4,764 | 1,90E-06 | intronic | PRKCA |
| rs551160836 | 18 | 41413084 | G | T | −0,014 | 0,009 | 0,078 | 0,058 | 0,012 | 0,069 | −4,923 | 8,49E-07 | intergenic | SYT4,LINC01478 |
| rs8111212 | 19 | 6166665 | T | C | −0,015 | 0,004 | 0,602 | 0,022 | 0,007 | 0,600 | −4,581 | 4,65E-06 | intronic | ACSBG2 |
| rs389332 | 21 | 18270964 | G | C | −0,018 | 0,008 | 0,939 | 0,056 | 0,014 | 0,934 | −4,425 | 9,65E-06 | intergenic | MIR99AHG,LINC01549 |
| rs9974620 | 21 | 36097794 | C | T | −0,006 | 0,005 | 0,713 | 0,037 | 0,007 | 0,687 | −4,922 | 8,56E-07 | ncRNA_intronic | LINC00160 |
*For beta interaction, positive values indicate association of allele A1 and increased cIMT; negative values indicate association of allele A1 with decreased cIMT.
ΨA1 is reflecting the alternative allele compared to the reference genome allele, all frequencies are reported for A1.