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. 2020 Feb 6;11:25. doi: 10.3389/fphar.2020.00025

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Copyright © 2020 Zhu, Liu, Zhao, Zhao, Gao and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Celastrol (Cel) disrupted the microvascular structure of glioma orthotopic xenografts. (A) Microvascular morphology in the tumors imaged by Transmission Electron Microscopy revealed that Cel disrupted the tight junctions (J) and the basal lamina structure (B) of microvasculature, vesicles (white arrows) and membrane protrusions (black arrows) linked to endothelial cells in the tumor microvascular lumen were also observed. (B) Immunofluorescence localization of ZO-1 and caveolin-1 in tumor microvasculature. ZO-1 (red) and caveolin-1 (green) were labelled with fluorescent secondary antibodies, and the nuclei were labelled with DAPI. (C) Western blot analysis of ZO-1 and caveolin-1 expression. The data are expressed as the mean ± SEM of three independent experiments, *P < 0.05, **P < 0.01, ***P < 0.001.