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. 2020 Feb 6;11:25. doi: 10.3389/fphar.2020.00025

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Copyright © 2020 Zhu, Liu, Zhao, Zhao, Gao and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Celastrol decreased the expression of the VM-related proteins EphA2 and VE-cadherin in glioma orthotopic xenografts. (A) Immunofluorescence localization of EphA2 and VE-cadherin in tumor vessels. EphA2 and VE-cadherin (green) were labelled with fluorescent secondary antibodies, and the nuclei were labelled with DAPI. (B) Western blot analysis of EphA2, VE-cadherin expressions in tumor tissues. (C) The expression of EphA2 in tumor patients and normal adults. GBM (glioblastoma), T (tumor patients), N (normal adults). (D) The survival analysis of EphA2 via GEAPIA Database. The data are expressed as the mean ± SEM of three independent experiments, *P < 0.05, ***P < 0.001.