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Microtubule (MT)-mediated transport of ER tubules. (1) Tip attachment complex (TAC) is formed between a MT plus end and the tip of an ER tubule through STIM1-EB1 interaction, resulting in movement of the ER tubule when the MT grows or retracts. (2) In ER sliding mechanism, the tip of an ER tubule associates to MTs, where motor proteins kinesin and dynein mediates, respectively, anterograde and retrograde movement of the ER tubule.
