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. 2020 Mar;26(3):229–239. doi: 10.1261/rna.073601.119

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© 2020 Khong and Parker; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 3. — Estimates of mRNA and RNA-BP concentrations in the nucleus and the cytoplasm. The estimates are derived from analyzing a number of data sets (Alberts 2002; Beck et al. 2011; Wühr et al. 2015; Piovesan et al. 2016; Khong et al. 2017) (see Supplemental Calculation #1). RNA-BPs are estimated to be ∼30-fold more concentrated in the nucleus than in the cytosol in U-2 OS cells. mRNA (in terms of RNA nucleotides) is ∼1.8-fold more concentrated in the nucleus than in the cytosol. Therefore, the ratio of RNA-BPs to mRNA sequences is higher in the nucleus than the cytoplasm (∼16.7-fold more RNA-BPs per nucleotide).