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rFVIIIFc affects signaling in both naïve and FVIII-exposed whole splenocytes. pSHIP and pERK levels in saline, anti-Ig (20 μg/ml), FVIII (11.4 μg/ml), and rFVIIIFc (14.7 μg/ml) stimulated (A,B) naïve and (C,D) FVIII-exposed splenocytes. Ratios of phosphorylated to total protein were obtained through densitometry analysis of three different blots. n = 3/condition. Error bars represent SD.
