Table 1.
Regression grading systems applied in the study.
| College of American Pathologist (CAP) (10) |
|
• Grade 0: no viable cancer cells (complete response) • Grade 1: single cells or rare small groups of cancer cells (near complete response) • Grade 2: residual cancer with evident tumor regression, but more than single cells or rare small groups of cancer cells (partial response) • Grade 3: extensive residual cancer with no evident tumor regression (poor or no response) |
| MD Anderson (12) |
|
• Grade 0: no residual carcinoma • Grade 1: patients with minimal residual carcinoma (single cells or small groups of cancer cells, <5% residual carcinoma) • Grade 2: patients with 5% or more residual carcinoma |
| Evans (20) |
|
• Grade I: characteristic cytologic changes of malignancy are present, but little (<10%) or no tumor cell destruction is evident. • Grade II: in addition to characteristic cytologic changes of malignancy, 10-90% of tumor cells are destroyed ▪ IIa: destruction of 10-50% of tumor cells ▪ IIb: destruction of 51-90% of tumor cells • Grade III: few (<10%) viable-appearing tumor cells are present ▪ IIIM: sizable pools of mucin are present • Grade IV: no viable tumor cells are present ▪ IVM: acellular pools of mucin are present |
| Hartman (21) |
|
• Marked Response: no residual tumor or rare, single cancer cells or small groups of cancer cells (glands) with marked cytopathic effect present within a fibrotic stroma • Minimal to Moderate Response: Residual tumor present; includes small groups of cells/glands without evidence of cytopathic effect, cells/ glands outside the main fibrotic mass, and/or 0.5% of the main fibrotic mass with cancer/glands, with or without cytopathic effect • Poor Response: No definite evidence of treatment effect; extensive (90%) residual cancer; only minimal cytopathic effect, and baseline fibrosis is present |
| iDworak (16) |
|
• Grade 0: dominant tumor mass with poor fibrosis • Grade 1: dominant tumor mass with obvious fibrosis • Grade 2: dominant fibrotic tissue with few neoplastic cells/glands, easy to find • Grade 3: dominant fibrotic tissue with very few neoplastic cells/glands, difficult to find • Grade 4: complete regression |