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. 2020 Jan 28;10:5. doi: 10.3389/fcimb.2020.00005

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Copyright © 2020 Resende, Oliveira, Guañabens, Repolês, Santana, Hiraiwa, Pena, Franco, Macedo, Tahara, Fragoso, Andrade and Machado.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dormancy in amastigote forms of T. cruzi CL Brener Rad51^+/−. (A) The graph shows the percentage of infected cells in LLC-MK2 cultures infected by T. cruzi CL Brener Rad51^+/− mutants and WT cells. The number of 250 LLC-MK2 cells were analyzed (parasites labeled with anti-T. cruzi antibody were disregarded). Asterisk indicate statistically significant differences between strains (P-value <0.05). (B) The graph shows the rate of intracellular parasitic replication in LLC-MK2 cultures exposed to T. cruzi CL Brener Rad51^+/− mutants and WT cells during 96 h of parasite exposure. A total of 100 infected LLC-MK2 cells were analyzed at each time point. (C) Percentage of intracellular parasites from T. cruzi CL Brener Rad51^+/− mutants and WT cells showing high CFSE labeling 96 h post-infection. One hundred infected LLC-MK2 cells were analyzed, and the percentage of CFSE-positive ones in relation to the total number of intracellular parasites was determined.