TABLE 1.

Selected genetic HD mouse models*.

Model	Type of genetic manipulation	References
R6/2	Transgenic, human exon 1 fragment with ∼150 CAG repeats under human HTT promoter	Mangiarini et al., 1996
YAC128	Transgenic, human full-length HTT with 128 CAG repeats	Slow et al., 2003
BACHD	Transgenic, human full-length HTT with 97 mixed CAA-CAG repeats	Gray et al., 2008
CAG140	Knock-in, chimeric mouse/human exon 1 with 140 CAG repeats inserted into the murine Htt locus	Menalled et al., 2003
zQ175	Knock-in derived from the CAG140 line, 188 CAG repeats	Menalled et al., 2012

*This table is not intended to give a complete overview of existing mouse models of HD, but only contains the models widely used for circuits studies.