Figure 4.

The effects of heterozygous p53-R280T and wt-p53 knockout on anchorage-independent and xenograft growth of NPC cells. (A) Representative results (left) and statistical analyses (right) of soft agar colony formation ability in p53 KO CNE2 and C666-1 cells and their control cells. (B) The photography of xenograft tumors 18 days after subcutaneous implantation of p53 KO CNE2 cells and control cells (left), and growth curve and weight of xenograft tumors generated by p53 KO CNE2 cells and control cells (middle and right). n = 3 mice per group. ***P < 0.001. KO, p53 knockout.