Table 2.

Advantages and Challenges of MSC Based Therapy and MSC Exosome Based Therapy

Type of Therapy	Advantages	Challenges
MSC based therapy	Potential of proliferation and differentiation, release of exosomes and other biological factors	Malignant transformation, tumor generation, microvascular obstruction
MSC Exosome based therapy	No apparent adverse effects, capability to cross the blood brain barrier, no vascular obstructive effects, easy to be stored and engineered	Determine the specific benefits and mechanisms of exosome administration, indepth study of exosome contents, potential side effects: tumor promotion