Table 2.
Change in exercise behaviors and fitness by treatment arm
| Measurement | Metformin + exercise (arm 1) absolute change, minutes (SE) | P arm 1 vs 4* | Exercise only (arm 2) absolute change (SE) | P arm 2 vs 4* | Metformin only (arm 3) absolute change (SE) | P arm 3 vs 4* | Control (arm 4) absolute change (SE) | P arm 1 vs 2† | P arm 1 vs 3† |
|---|---|---|---|---|---|---|---|---|---|
| Exercise, min/wk | 166.6 (16.4) | < .0001 | 140.3 (16.4) | < .0001 | 26.9 (17.7) | 0.69 | 30.2 (19.4) | .07 | < .0001 |
| Physical activity, MET h/wk | 13.6 (1.26) | < .0001 | 11.3 (1.26) | < .0001 | 2.40 (1.36) | 0.65 | 2.76 (1.49) | .04 | < .0001 |
| Walking distance in 6 min, ft | 105.4 (23.6) | .02 | 81.9 (24.5) | .09 | −2.02 (26.1) | 0.92 | 39.9 (28.2) | .20 | < .0001 |
*
One-sided P tests if the decrease in treatment arms is greater than in the control arm. Analyses by mixed modeling. MET = metabolic equivalent task.
†
One-sided P tests if the decrease in the combined arm is greater than in the exercise-only arm or metformin-only arm.