Table 4.

Toxicity for metformin, highest grade for each patient

	Metformin + exercise, No. (%)				Metformin only, No. (%)
Toxicity	Any grade	Grade 1	Grade 2	Grade 3	Any grade	Grade 1	Grade 2	Grade 3
Diarrhea	14 (40)	8 (22.9)	2 (5.7)	2 (5.7)	8 (22.9)	6 (17.1)	1 (2.9)	1 (2.9)
Nausea	5 (14.3)	4 (11.4)	0	1 (2.9)	9 (25.7)	6 (17.1)	3 (8.6)	0
Abdominal Pain	6 (17.1)	5 (14.3)	1 (2.9)	0	6 (17.1)	4 (11.4)	1 (2.9)	1 (2.9)
Vomiting	3 (8.6)	2 (5.7)	0	1 (2.9)	7 (20.0)	3 (8.6)	4 (11.4)	0
Bloating	3 (8.6)	1 (2.9)	2 (5.7)	0	3 (8.6)	1 (2.9)	2 (5.7)	0
Flatulence	4 (11.4)	3 (8.6)	1 (2.9)	0	2 (5.7)	1 (2.9)	1 (2.9)	0
Fatigue	2 (5.8)	1 (2.9)	1 (2.9)	0	2 (5.7)	1 (2.9)	1 (2.9)	0