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. 2020 Feb 13;13:365–375. doi: 10.2147/DMSO.S225791

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© 2020 Zhu et al.

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KCNQ1OT1 interference alleviated the oxidative stress in HG-induced HK-2 cells. (A) ROS level was increased in HG-induced HK-2 cells and KCNQ1OT1 expression was decreased in HG-induced HK-2 cells transfected with shRNA-KCNQ1OT1-1. **P<0.01 and ***P<0.001 vs. control group. ^###P<0.001 vs. control+HG group. ^∆∆∆P<0.001 vs. shRNA-NC+HG group. (B) MDA level was increased in HG-induced HK-2 cells and KCNQ1OT1 expression was decreased in HG-induced HK-2 cells transfected with shRNA-KCNQ1OT1-1. **P<0.01 and ***P<0.001 vs. control group. ^##P<0.01 vs. control+HG group. ^∆P<0.05 vs. shRNA-NC+HG group. (C) SOD level was decreased in HG-induced HK-2 cells and KCNQ1OT1 expression was increased in HG-induced HK-2 cells transfected with shRNA-KCNQ1OT1-1. ***P<0.001 vs. control group. ^##P<0.01 vs. control+HG group. ^∆∆P<0.01 vs. shRNA-NC+HG group. (D) ROS level was verified by the images of immunofluorescence. (n=3).