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. 2020 Feb 13;13:365–375. doi: 10.2147/DMSO.S225791

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© 2020 Zhu et al.

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KCNQ1OT1 interference decreased the pyroptosis of HG-induced HK-2 cells. (A) The protein expression of NLRP3, cleaved-caspase1, IL-1β and GSDMD-N was decreased in HG-induced HK-2 cells and increased in HG-induced HK-2 cells transfected with shRNA-KCNQ1OT1-1. *P<0.05, **P<0.01 and ***P<0.001 vs. control group. ^#P<0.05 and ^##P<0.01 vs. control+HG group. ^∆P<0.05 and ^∆∆P<0.01 vs. shRNA-NC+HG group. (B) The mRNA expression of NLRP3, cleaved-caspase-1, IL-1β and GSDMD-N was decreased in HG-induced HK-2 cells and increased in HG-induced HK-2 cells transfected with shRNA-KCNQ1OT1-1. **P<0.01 and ***P<0.001 vs. control group. ^#P<0.05, ^##P<0.01 and ^###P<0.001 vs. control+HG group. ^∆P<0.05 and ^∆∆P<0.01 vs. shRNA-NC+HG group. (C) GSDMD-N expression was verified by the images of immunofluorescence. (n=3).