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. 2020 Feb 13;13:365–375. doi: 10.2147/DMSO.S225791

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© 2020 Zhu et al.

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KCNQ1OT1 directly targeted miR-506-3p. (A) The putative target sequence for KCNQ1OT1 on the 3ʹ-UTR of miR-506-3p. (B) Luciferase reporter analysis showed the target role of KCNQ1OT1 on the 3ʹ-UTR of miR-506-3p. **P<0.01 vs. miR-506-3p+pcDNA-NC group; UTR, untranslated region; WT, wild-type; MUT, mutated. (C) miR-506-3p expression was decreased in HG-induced HK-2 cells and miR-506-3p expression was increased in HG-induced HK-2 cells transfected with shRNA-KCNQ1OT1-1. ***P<0.001 vs. control group. ^#P<0.05 vs. control+HG group. ^∆∆P<0.01 vs. shRNA-NC+HG group. (D) miR-506-3p expression was down-regulated in the plasma of patients with DN. ***P<0.001 vs. control group. (n=3).