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. 2020 Feb 14;8:e8504. doi: 10.7717/peerj.8504

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©2020 Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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(A–E) Relationship between overall survival (OS) and the five key hub genes (COL8A1, FRMD6, TIMP2, CNRIP1, GPR124) in the training dataset. Kaplan-Meier survival curve plots for OS are shown (gastric cancer patients were grouped by the median of the expression level of hub genes). Increased expression of the five genes indicated poor overall survival. Additionally, the relationship between OS and the five key hub genes in the validation dataset was presented in (F–J). Red lines represent high expression of the real hub genes and blue lines represent low expression. The “+” symbol in the panel indicated censored data. The dashed line in KM curves mean the median survival. It defined that the survival time corresponding to a cumulative survival rate of 0.5 means that only 50% of individuals can live this time.