Table 3. Relationships between hub genes in module brown with OS/DFS in the training and validation datasets.
| Gene | Training dataset (n = 300) | Validation dataset (n = 248) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| OS | DFS | OS | |||||||
| HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value | |
| COL8A1 | 1.573 | 1.139–2.171 | 0.006** | 1.468 | 1.063–2.026 | 0.020* | 2.5 | 1.72–3.632 | 0.000*** |
| FRMD6 | 1.615 | 1.17–2.231 | 0.004** | 1.557 | 1.127–2.15 | 0.007** | 1.591 | 1.104–2.292 | 0.013* |
| DDR2 | 1.612 | 1.167–2.226 | 0.004** | 1.521 | 1.101–2.1 | 0.011* | 1.71 | 1.187–2.463 | 0.004** |
| LOC100505881 | 1.549 | 1.122–2.138 | 0.008** | 1.477 | 1.07–2.039 | 0.018* | 1.792 | 1.241–2.589 | 0.002** |
| TIMP2 | 1.574 | 1.141–2.171 | 0.006** | 1.446 | 1.049–1.995 | 0.024* | 1.943 | 1.347–2.803 | 0.000*** |
| CNRIP1 | 1.537 | 1.113–2.121 | 0.009** | 1.457 | 1.056–2.01 | 0.022* | 1.36 | 0.949–1.948 | 0.094 |
| CLEC11A | 1.706 | 1.235–2.356 | 0.001*** | 1.667 | 1.207–2.303 | 0.002** | 1.44 | 1.004–2.065 | 0.047* |
| MRC2 | 1.652 | 1.194–2.284 | 0.002** | 1.543 | 1.117–2.133 | 0.009** | 1.599 | 1.112–2.3 | 0.011* |
| BGN | 1.613 | 1.168–2.229 | 0.004** | 1.564 | 1.132–2.16 | 0.007** | 1.978 | 1.368–2.858 | 0.000*** |
| GPR124 | 1.929 | 1.39–2.677 | 0.000*** | 1.878 | 1.353-2.606 | 0.000*** | 1.572 | 1.094–2.259 | 0.014* |
Notes.
*
p ≤ 0.05.
**
p ≤ 0.01.
***
p ≤ 0.001.
Overall survival (OS), Disease-free survival (DFS). Hazard ratios (HRs), 95% confidence intervals (CI), and p-values were calculated using Cox proportional hazards regression analysis after grouped the gastric cancer patients by the median of gene level.