Table 1.
PRR-targeted particles for vaccination
| PRR | Ligand | Delivery vehicle | Antigen | Refs. |
|---|---|---|---|---|
| TLR 1/2 | Pam3CAG | Liposome | Hemagglutinin peptide | [49] |
| TLR 2/6 | Pam2CAG | [49] | ||
| TLR 3 | Poly (I:C) | PLGA MP | N/A | [53] |
| TLR 3 | Poly (I:C) | Polyketal MP | Ovalbumin | [54] |
| TLR 3 | Poly (I:C) | Liposome | Ovalbumin | [55] |
| TLR 4 | LPS | Liposome | HBsAg | [75] |
| TLR 4 | LPS | Gelatin MP | BSA | [78] |
| TLR 4/NLRP3 | LPS | PLGA NP | Ovalbumin, WNV envelope protein | [79] |
| TLR 4 | Lipid A | Liposome | Malaria antigen | [121] |
| TLR 4 | MPLA | Liposome (Stimuvax) | N/A | Merck |
| TLR 4 | MPLA | Liposome (AS01) | N/A | GSK |
| TLR 4 | MPLA | PLGA NP | MUC1 lipopeptide | [83] |
| TLR 4 | MPLA | PLGA NP | HBcAg | [84] |
| TLR 5 | Flagellin | Polyanhydride NP | Ovalbumin | [89] |
| TLR 5 | Flagellin | Polypropylene sulfide NP | Ovalbumin | [90] |
| TLR 7 | 3M019 | Liposome | Ovalbumin | [61] |
| TLR 9 | Plasmid DNA | Liposome | HBsAg | [65] |
| TLR 9 | CpG ODN | Liposome | Hemagglutinin, Neuraminidase, HBsAg | [68] |
| TLR 9 | CpG ODN | Liposome | Ovalbumin | [69,66] |
| TLR 9 | CpG ODN | Gelatin NP | N/A | [72] |
| TLR 9 | CpG ODN | PLGA MP | p55 gag, gp120 env (HIV-1) | [69] |
| TLR 9 | CpG ODN | Alginate-coated chitosan NP | HBsAg | [70] |
| TLR 9 | CpG ODN | PLGA NP | WNV envelope protein | [73] |
| Mincle | TDM | CAF01 | Mycobacterial antigens | [101] |
| Dectin-1 | β-Glucan | β-Glucan | Ovalbumin | [99] |
| NOD2 | MDP | Liposome | HBsAg | [122] |
| NOD2 | MDP | Liposome | Mycobacterial antigens | [117] |
| NOD2 | MDP | Gelatin MP | BSA | [78] |
Abbreviations: BSA, bovine serum albumin; HBsAg/HBcAg, Hepatitis B surface/core antigen; NP, nanoparticle; MP, microparticle; WNV, West Nile virus.