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. 2020 Feb 13;13:1303–1310. doi: 10.2147/OTT.S233495

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© 2020 Zhang et al.

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Loss of KLF16 results in inhibition of MYC signaling. (A) Gene set enrichment analysis (GSEA) was performed based on oncogenic signatures that disrupt KLF16 in PC3 cells. The results are shown in rank order of p-value and enrichment scores. (B) GSEA of the profile data inhibiting expression of KLF16 in PC3 cells based on the gene set of MYC signaling in the control (left) and shKLF16 (right). (C, D) GSEA of the TCGA and MSKCC datasets based on the MYC signaling gene set and KLF16 transcription levels. (E) PC3 and 22RV1 cells were infected with the indicated shRNAs virus, and the indicated proteins were detected by Western blot. The semi-quantitation of Western blotting was shown under the pictures.