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. 2020 Feb 13;13:1321–1330. doi: 10.2147/OTT.S239407

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© 2020 Luo et al.

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DUSP9 inhibits mTOR pathway activation. (A) Western blot analysis demonstrated inhibition of mTOR phosphorylation by the overexpression of DUSP9 in 769-P and 786-O cells at Ser2448. (B, C and D) Western blot and q-PCR analysis indicated overexpression of DUSP9 to inhibit Sox2, c-Myc, and HIF-1α protein and mRNA expression in 769-P and 786-O cells; **p < 0.01, ***p < 0.001. All data were representatives of three independent experiments.

Abbreviations: DUSP9, dual specificity phosphatase 9; NC, negative control.