Fig. 5.7.

Structure of the open and initially transcribing human Pol II-PICs and comparison with their yeast counterparts. a Structure of the open human Pol-II PIC (He et al. 2016). b Structure of the human Pol II-ITC (He et al. 2016). RNA near the Pol II active site is shown in red. c Comparison to the structure of the yeast open complex (Plaschka et al. 2016) reveals overall conservation of PIC architecture. d–f DNA interactions of TFIIB in the human Pol II open complex (e) and ITC (f) (He et al. 2016). g Interaction between the TFIIE E-wing domain and bound promoter DNA in the yeast closed PIC (Plaschka et al. 2016). h In the human Pol II-PIC (He et al. 2016), the closed promoter DNA is inserted more deeply into the Pol II cleft, and the TFIIE-DNA interaction visualized in yeast is not present. i Human Pol II open PIC (He et al. 2016)