Sideri 1994.

Methods	This was a randomised controlled trial.
Participants	58 women with histologically confirmed vulval LS
Interventions	A: testosterone propionate 2% B: placebo (petrolatum ointment) These were taken for 1 year.
Outcomes	Outcomes of the trial 1) Symptoms 2) Gross appearance 3) Histological changes
Notes	Setting: university hospital Country: Italy Funding source: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	There was no description of the process of randomisation.
Allocation concealment (selection bias)	Unclear risk	There was no description of the allocation concealment.
Blinding (performance bias and detection bias) All outcomes	Low risk	Neither the investigator nor the participants knew which medicine was being applied.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	There was no description of withdrawal or dropout.
Selective reporting (reporting bias)	Low risk	Improvement in symptoms, gross appearance, and adverse drug reactions were reported.
Degree of certainty that the participants have LS	Low risk	LS was proven by biopsy.
Baseline assessment of the participants	Unclear risk	This was not performed.
Drug identity, source, dose, duration of treatments, and adequacy of instructions	Low risk	The treatments were standardised.
Description and standardisation of outcome measures	Unclear risk	Although a scoring system was used to assess clinical and symptomatic status, no relevant details were provided.
Discontinuation of previous treatments	Low risk	All participants received an initial 2‐week course of topical antibiotic‐corticosteroid cream before allocation, then they were randomised to the testosterone and placebo groups.
Permission or standardisation of concomitant treatments	Unclear risk	There was no relevant description.
Use and appropriateness of statistical analyses where tabulated data could not be extracted from the original publication	Low risk	We extracted tabulated data from the trial.

VAS= visual analogue scale
 PR=pruritus
 BP= burning/pain