Dominguez 1991.

Methods	Design: RCT parallel group, Blindness: double Duration of study: 13 week
Participants	Single or multicentre: Multicentre Diagnostic criteria: DSM IIIR Co‐morbidity allowed: Secondary depression including sever Setting: Out‐patients Age: 17‐70 yrs Other characteristics: Men and women
Interventions	No. of arms: four (fluoxetine 20mg vs 40mg vs 60mg vs placebo)
Outcomes	Primary: Change in YBOCS total score Proportion of responders (defined as 35% reduction in YBOCS)
Notes	2
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear