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. 2005 Jul 20;2005(3):CD001715. doi: 10.1002/14651858.CD001715.pub2

Comparison 2. SERTINDOLE versus HALOPERIDOL.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Leaving study early: 1. Any reason 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 1.13 [0.84, 1.52]
1.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.96 [0.71, 1.32]
1.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.94 [0.68, 1.28]
1.4 Sertindole 24mg 2 524 Risk Ratio (M‐H, Fixed, 95% CI) 0.81 [0.63, 1.05]
2 Leaving study early: 2. Any adverse event 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 17.70 [1.03, 303.37]
2.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 18.70 [1.10, 317.94]
2.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 12.70 [0.72, 223.04]
2.4 Sertindole 24mg 2 524 Risk Ratio (M‐H, Fixed, 95% CI) 1.28 [0.83, 1.97]
3 Leaving study early: 3. Abnormal blood chemistry values 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 5.0 [0.24, 103.22]
4 Leaving study early: 4. Due to leukopenia 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
4.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 5.0 [0.24, 103.22]
5 Leaving study early: 5. Due to prolonged QT intervals 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
5.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 2.0 [0.18, 21.81]
6 Leaving study early: 6. insufficient treatment response 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
6.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 1.27 [0.72, 2.25]
6.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 1.26 [0.71, 2.21]
6.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 1.03 [0.57, 1.87]
6.4 Sertindole 24mg 1 242 Risk Ratio (M‐H, Fixed, 95% CI) 1.07 [0.58, 1.95]
7 Leaving study early: 7. patient's decision 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
7.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 1.04 [0.55, 1.99]
7.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.68 [0.33, 1.40]
7.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.79 [0.40, 1.58]
7.4 Sertindole 24mg 1 242 Risk Ratio (M‐H, Fixed, 95% CI) 0.67 [0.32, 1.41]
8 Leaving study early: 8. non‐compliance 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
8.4 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 0.15 [0.04, 0.67]
9 Mental state: 1. Improvement in PANSS=30% 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
9.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 0.72 [0.56, 0.93]
9.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.97 [0.79, 1.20]
9.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.87 [0.70, 1.09]
9.4 Sertindole 24mg 1 242 Risk Ratio (M‐H, Fixed, 95% CI) 0.91 [0.73, 1.14]
10 Mental state: 2. Improvement in PANSS=40% 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
10.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 0.66 [0.48, 0.92]
10.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.97 [0.74, 1.27]
10.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.96 [0.73, 1.26]
10.4 Sertindole 24mg 1 242 Risk Ratio (M‐H, Fixed, 95% CI) 0.94 [0.71, 1.24]
11 Mental state: 3. Improvement in PANSS=50% 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
11.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 0.61 [0.40, 0.93]
11.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 1.05 [0.75, 1.47]
11.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.82 [0.57, 1.18]
11.4 Sertindole 24mg 1 242 Risk Ratio (M‐H, Fixed, 95% CI) 0.87 [0.60, 1.26]
12 Extrapyramidal adverse effects: 1. General ‐ extrapyramidal syndrome 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
12.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 0.09 [0.01, 0.66]
12.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.11, 0.99]
12.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.24 [0.07, 0.84]
12.4 Sertindole 24mg 2 524 Risk Ratio (M‐H, Fixed, 95% CI) 0.59 [0.43, 0.80]
13 Extrapyramidal adverse effects: 2. Akathisia 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
13.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 0.17 [0.06, 0.46]
13.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.08 [0.02, 0.33]
13.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.31 [0.15, 0.67]
13.4 Sertindole 24mg 2 524 Risk Ratio (M‐H, Fixed, 95% CI) 0.47 [0.31, 0.71]
14 Extrapyramidal adverse effects: 3. Dystonia 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
14.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 0.06 [0.00, 1.05]
14.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.06 [0.00, 0.99]
14.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.37 [0.10, 1.35]
14.4 Sertindole 24mg 1 242 Risk Ratio (M‐H, Fixed, 95% CI) 0.27 [0.06, 1.23]
15 Extrapyramidal adverse effects: 4. Hypertonia 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
15.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 0.40 [0.15, 1.09]
15.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.45 [0.18, 1.16]
15.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.68 [0.30, 1.52]
15.4 Sertindole 24mg 2 524 Risk Ratio (M‐H, Fixed, 95% CI) 0.45 [0.26, 0.76]
16 Extrapyramidal adverse effects: 5. Hypokinesia 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
16.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 0.15 [0.01, 2.85]
16.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.66 [0.11, 3.86]
16.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.65 [0.11, 3.83]
16.4 Sertindole 24mg 1 242 Risk Ratio (M‐H, Fixed, 95% CI) 2.14 [0.55, 8.35]
17 Extrapyramidal adverse effects: 6. Tremor 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
17.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 0.30 [0.12, 0.71]
17.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.19 [0.07, 0.53]
17.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.23 [0.09, 0.60]
17.4 Sertindole 24mg 2 524 Risk Ratio (M‐H, Fixed, 95% CI) 0.36 [0.22, 0.60]
18 Other adverse effects: 1. Any event 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
18.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 0.74 [0.62, 0.88]
18.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.73, 0.98]
18.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.82 [0.70, 0.96]
18.4 Sertindole 24mg 1 242 Risk Ratio (M‐H, Fixed, 95% CI) 0.87 [0.75, 1.00]
19 Other adverse effects: 2. Cardiovascular ‐ postural hypotension 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
19.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 1.04 [0.35, 3.14]
19.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 1.48 [0.54, 4.03]
19.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 1.79 [0.68, 4.69]
19.4 Sertindole 24mg 1 242 Risk Ratio (M‐H, Fixed, 95% CI) 2.67 [1.07, 6.65]
20 Other adverse effects: 3. Cardiovascular ‐ QTc interval=500msec 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
20.1 Sertindole 16mg 1   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
20.2 Sertindole 24mg 1   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
21 Other adverse effects: 4. Cardiovascular ‐ QT intervals exceeding 500msec 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
21.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 3.0 [0.12, 73.02]
22 Other adverse effects: 5. Cardiovascular ‐ QTc intervals of at least 500msec 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
22.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 23.0 [1.37, 386.58]
23 Other adverse effects: 6. Gastrointestinal ‐ dyspepsia 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
23.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 0.06 [0.00, 1.05]
23.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.06 [0.00, 0.99]
23.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.37 [0.10, 1.35]
23.4 Sertindole 24mg 2 524 Risk Ratio (M‐H, Fixed, 95% CI) 0.57 [0.30, 1.07]
24 Other adverse effects: 7. Gastrointestinal ‐ nausea 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
24.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.54, 1.84]
25 Other adverse effects: 8. Gastrointestinal ‐ vomiting 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
25.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 0.69 [0.33, 1.43]
26 Other adverse effects: 9. Sleep related ‐ somnolence 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
26.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 0.09 [0.01, 0.66]
26.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.49 [0.19, 1.27]
26.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.41 [0.15, 1.12]
26.4 Sertindole 24mg 2 524 Risk Ratio (M‐H, Fixed, 95% CI) 0.64 [0.43, 0.95]
27 Other adverse effects: 10. Sleep related ‐ insomnia 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
27.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 0.92 [0.66, 1.28]
28 Other adverse effects: 11. Accidental injury 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
28.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 0.6 [0.27, 1.33]
29 Other adverse effects: 12. Asthenia 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
29.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 0.43 [0.16, 1.19]
29.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.57 [0.23, 1.41]
29.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 0.81 [0.36, 1.82]
29.4 Sertindole 24mg 2 524 Risk Ratio (M‐H, Fixed, 95% CI) 0.91 [0.55, 1.51]
30 Other adverse effects: 13. Coughing 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
30.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.51, 1.97]
31 Other adverse effects: 14. Dizziness 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
31.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 1.04 [0.43, 2.53]
31.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 0.66 [0.24, 1.79]
31.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 1.41 [0.63, 3.18]
31.4 Sertindole 24mg 2 524 Risk Ratio (M‐H, Fixed, 95% CI) 0.96 [0.61, 1.50]
32 Other adverse effects: 15. Dry mouth 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
32.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 1.83 [0.94, 3.56]
33 Other adverse effects: 16. Headache 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
33.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 1.11 [0.58, 2.15]
33.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 1.05 [0.54, 2.03]
33.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 1.24 [0.66, 2.32]
33.4 Sertindole 24mg 2 524 Risk Ratio (M‐H, Fixed, 95% CI) 1.23 [0.90, 1.68]
34 Other adverse effects: 17. Infection 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
34.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 0.94 [0.61, 1.45]
35 Other adverse effects: 18. Myalgia 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
35.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 0.91 [0.53, 1.57]
36 Other adverse effects: 19. Overdose 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
36.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 0.47 [0.21, 1.05]
37 Other adverse effects: 20. Psychosis 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
37.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 0.65 [0.31, 1.33]
38 Other adverse effects: 21. Rhinitis 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
38.1 Sertindole 8mg 1 245 Risk Ratio (M‐H, Fixed, 95% CI) 4.17 [0.47, 36.75]
38.2 Sertindole 16mg 1 252 Risk Ratio (M‐H, Fixed, 95% CI) 10.83 [1.42, 82.61]
38.3 Sertindole 20mg 1 253 Risk Ratio (M‐H, Fixed, 95% CI) 3.91 [0.44, 34.47]
38.4 Sertindole 24mg 2 524 Risk Ratio (M‐H, Fixed, 95% CI) 2.09 [1.39, 3.13]
39 Other adverse effects: 22. Weight gain 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
39.1 Sertindole 24mg 1   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
40 Service utilisation: 1. Requiring psychiatric hospitalisation 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
40.1 Sertindole 24mg 1 282 Risk Ratio (M‐H, Fixed, 95% CI) 0.17 [0.04, 0.73]