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| Methods | multicentre, double blind, randomized, placebo controlled, parallel groups | |
| Participants | Hypertension & leukoaraiosis; 36 patients received nicergoline, 36 placebo; age > 60 yr. | |
| Interventions | Nicergoline or Placebo 30mg. twice a day (os) for 24 months | |
| Outcomes | Rey Auditory Verbal Learning Test | |
| Notes | ITT (LOCF) analysis is available | |
