Hafstrom.

Methods	Multicentre randomised controlled trial. Generation of allocation schedule truly random. Concealment of allocation adequate (personal communication with investigator)
Participants	60 patients with non‐resectable liver metastases and no extrahepatic cancer. Age<= 75 years.
Interventions	Temporary hepatic artery occlusion with intraportal infusion of 5‐Fluorouracil (1000mg/m2/day) for 5 days plus allopurinol 300mg p.o. for 10 days. Repeated every 6 weeks until progression. After 2 years, interval between treatments was prolonged. vs Control : no regional or systemic treatment
Outcomes	Overall survival, Tumour response, Complications
Notes	57 of 60 randomised patients were treated at one centre. 6 patients were excluded after randomisation because of major protocol violations (not intention to treat) 5/32 in treatment group and 3/28 in control group had subsequent systemic chemotherapy
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate