Hunt.

Methods	Single centre randomised controlled trial. Generation of allocation schedule truly random.
Participants	61 patients with unresectable liver metastases and no evidence of extrahepatic disease. Karnofsky score >60. Age 18‐75 years. Fit enough to undergo laparotomy. Patients excluded if extensive disease (jaundice, ascites, percentage liver replacement >75%)
Interventions	Hepatic artery injection of 5‐Fluorouracil (500mg) plus Degradable starch microspheres (300‐900mg). First course consisted of 4 injections on consecutive days. Each subsequent course consisted of 2 injections on consecutive days, repeated every 28 days. vs Hepatic artery embolisation vs No active therapeutic intervention. Symptomatic treatment provided where necessary
Outcomes	Overall survival, Extrahepatic disease, Toxicity, Complications
Notes	Analysis was by intention to treat.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate