Scheithauer.

Methods	Single centre randomised controlled trial. Generation of allocation schedule by computer generated random number list (adequate). Ratio of chemotherapy to supportive care 2:1.
Participants	40 previously untreated patients with inoperable, locally recurrent or metastatic colorectal cancer. Age < 75 yrs, life expectancy > 2 months, ECOG performance status <=3. Specified levels of haematological, renal and hepatic function for inclusion.
Interventions	Leucovorin bolus i.v. (200mg/m2/day) plus 5‐Fluorouracil bolus i.v. (550mg/m2/day) plus Cisplatin infusion (20mg/m2/day). All drugs given on 4 consecutive days at 4 week intervals. Continued for total of 6 months or until evidence of disease progression vs Supportive care : analgesia, nutritional support, blood transfusion, and psychosocial support as required.
Outcomes	Survival, Quality of life, Toxicity
Notes	2/12 evaluable patients in supportive care group received chemotherapy. Analysis not by intention to treat as 4 patients were withdrawn after randomisation.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate