Yorkshire.

Methods	Multicentre randomised controlled trial. Generation of allocation schedule unclear.
Participants	57 patients with minimal residual malignant disease after palliative resection for colorectal cancer
Interventions	Methyl CCNU (130mg/m2 i.v. day 1) plus 5‐Fluorouracil (300mg/m2/day i.v. days 1‐5). Courses repeated every 8 weeks for 2 years, unless signs of disease progression vs Symptomatic treatment only
Outcomes	Survival, Progression, Toxicity
Notes	Paper does not report whether patients in the control group received subsequent systemic chemotherapy. Analysis not by intention to treat as some patients were withdrawn from analysis after randomisation.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear