Allen Mersh.

Methods	Single centre randomised controlled trial. Generation of allocation schedule by minimisation.
Participants	100 patients with synchronous or metachronous colorectal liver metastases, excluding those with extensive metastases (>60% liver replacement), less than 4 discrete resectable metastases, ascites, raised bilibubin, evidence of disease outside the liver or a history of systemic chemotherapy. Age < 75 years
Interventions	Hepatic artery infusion Floxuridine (0.2 mg/kg body weight). 14‐day continuous infusion followed by 14‐day rest, and cycle repeated. Treatment continued until progression or toxicity. vs Conventional palliation : resection of primary tumour if diagnosed synchronously. Analgesia, corticosteroids, and systemic chemotherapy permitted. Hepatic artery infusion was not allowed.
Outcomes	Overall survival, Quality of life, Toxicity
Notes	Paper suggests that most of the control group (39/49) did not receive systemic chemotherapy in addition to conventional palliation. Analysis was by intention to treat
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate