Chisholm.

Methods	Single centre randomised controlled trial. Generation of allocation schedule unclear.
Participants	46 patients with locally advanced or disseminated colorectal cancer
Interventions	5‐Fluorouracil (500‐750mg), methotrexate (25‐50mg) and cyclophosphamide (100‐200mg) i.v. every 2 weeks + Prednisolone (5mg b.d. p.o.) vs Supportive treatment only
Outcomes	Survival, Toxicity
Notes	Only published as an abstract. Cannot tell whether analysis was by intention to treat.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear