Gerard.

Methods	Multicentre randomised controlled trial. Generation of allocation schedule truly random (personal communication with investigator). Stratified according to measurability of lesion and presence / absence of symptoms
Participants	74 patients with unresectable colorectal liver metastases. Primary colorectal adenocarcinoma had been resected during previous surgical operation. Age < 70 years, Karnofsky performance score >= 60.
Interventions	Hepatic artery ligation with portal infusion 5‐Fluorouracil 600mg/m2/day for at least 10 days (max. 20 days) . Treatment repeated every 6 weeks until progression or severe side effects vs Hepatic artery ligation alone
Outcomes	Survival, Progression, Tumour response, Complications, Toxicity
Notes	Paper does not report whether patients in the control group received subsequent systemic chemotherapy. Analysis not by intention to treat as 7 patients withdrawn from analysis after randomisation.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate