Rosenfeld 1984.

Methods	Blinding of randomization: Can't tell Blinding of intervention: Yes Complete follow‐up: No Blinding of outcome measurement: Yes for radiologic evaluation. No for other outcomes.
Participants	Preterm infants admitted to the neonatal intensive care unit with respiratory distress syndrome, ventilator dependent with fraction of inspired oxygen > 0.70 at 24 hours of age to maintain PaO2 > or = 50 torr.
Interventions	Experimental: Bovine superoxide dismutase 0.25 mg/kg subcutaneously every 12 hours until no longer needing ventilator or continuous positive airway pressure and maintained on room air (n=21). Control (Placebo): Equal volume of saline subcutaneously (n=24).
Outcomes	Radiologic changes of bronchopulmonary dysplasia.
Notes	Study done in pre‐surfactant era. Definition of bronchopulmonay dysplasia different from current definition. Small sample size.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear