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. 2008 Jan 23;2008(1):CD001537. doi: 10.1002/14651858.CD001537.pub4

Yeung 1983.

Methods Country: Hong Kong 
 Setting/Design:Single university centre RCT 
 Time Frame: NS 
 Randomisation method: NS 
 Blinding 
 ‐ Participants: No 
 ‐ Investigators: No 
 ‐ Outcome assessors: NS 
 ‐ Data analyses: NS 
 Intention‐to‐treat: No 
 Follow‐up period: Up to 750 days 
 Loss to follow‐up: NS
Participants INCLUSION CRITERIA 
 Biopsy‐proven minimal change nephrotic syndrome, first episode
GROUP 1 (methylprednisolone) 
 Number: 10 (1 F) 
 Age: mean 29.0 y
GROUP 2 (prednisone) 
 Number: 8 (3 F) 
 Age: mean 22.4 y
Interventions GROUP 1 
 Methylprednisolone 20 mg/kg/d IV on three consecutive days; then prednisone 1‐2 mg/kg/d 2 weeks after methylprednisolone dose as maintenance if response to methylprednisolone. 
 If no response within 2 weeks re‐allocated to oral prednisone.
GROUP 2 
 Prednisone 1 mg/kg/d for 4‐6 weeks
COINTERVENTIONS 
 Diuretics
Outcomes

  1. Complete remission

  2. Time to complete remission (days)

  3. Duration of first remission

  4. Treatment related toxicity
Notes Exclusions post‐randomisation but pre‐intervention: NS 
 Additional data requested from authors: Study quality data
COMPLETENESS OF FOLLOW‐UP 
 Eligible/considered for inclusion = NS; Enrolled/randomised = 18; Analysed = 18 ; Percent followed = 100
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear

MCD ‐ minimal change disease; NS ‐ not stated