Coggins 1985.
Methods | Country: United States Setting/Design: Collaborative placebo‐controlled RCT Time Frame: NS Randomisation method: NS Blinding ‐ Participants: NS ‐ Investigators: NS ‐ Outcome assessors: NS ‐ Data analyses: NS Intention‐to‐treat: NS Follow‐up period: 77 months Loss to follow‐up: 0% | |
Participants | INCLUSION CRITERIA
Idiopathic nephrotic syndrome of minimal change disease GROUP 1 (prednisone) Number: 14 Age: 29 years GROUP 2 (no treatment) Number: 14 Age: 32 years |
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Interventions | GROUP 1
Prednisone 125 mg PO given in alternate‐day doses for 2 months.
Relapses were re‐treated. GROUP 2 No treatment. If patient reached "stop points" (including doubling of admission creatinine) they were withdrawn from the placebo group and treated with steroids. COINTERVENTIONS: NS |
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Outcomes |
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Notes | Exclusions post‐randomisation but pre‐intervention: NS
Additional data requested from authors: Method of randomisation, allocation concealment COMPLETENESS OF FOLLOW‐UP Eligible/considered for inclusion = NS; Enrolled/randomised = 28; Analysed = 28 ; Percent followed = 100 |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |