Ksiazek 1995.

Methods	Study design: parallel RCT Time frame: not reported Follow‐up: two years
Participants	Country: Poland Setting: renal clinic Inclusion criteria: children with initial episode SSNS Number: treatment group 1 (72); treatment group 2 (68); treatment group 3 (44) Mean age (range): 3.6 years (13 months to 11 years) Sex (M/F): 113/71 Exclusion criteria: not reported
Interventions	Treatment group 1 (6 months) Prednisone: 1 to 2 mg/kg/d for 4 weeks, 1 mg/kg on alternate days for 4 weeks and taper by 25% each month for 4 months Total duration: 6 months Total calculated steroid dose 2922 mg/m2 Treatment group 2 (3 months) Prednisone 1 to 2 mg/kg/d for 4 weeks, 1 mg/kg on alternate days for 4 weeks and taper by 25%/week for 4 weeks. Total duration: 3 months Total calculated steroid dose 2410 mg/m2 Treatment group 3 (2 months) Prednisone 4 weeks each of 1 to 2 mg/kg/d and 1 mg/kg on alternate days Total duration: 2 months
Outcomes	Number relapsing by 6 months and 2 years after completing daily and alternate‐day prednisone Relapse rate/patient/y
Notes	Unequal numbers in groups Only treatment group 2 used in analyses Definitions FRNS: ISKDC definition Relapse: ISKDC definition Remission: ISKDC definition
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"randomly assigned", insufficient information about sequence generation to permit judgement
Allocation concealment (selection bias)	High risk	"Parents had an influence on assignment, favouring Protocol C"
Blinding of participants and personnel (performance bias) All outcomes	High risk	Blinding not reported and the outcome is likely to be influenced by lack of blinding
Blinding of outcome assessment (detection bias) All outcomes	High risk	Blinding of outcome assessment not reported and outcome measurement likely to be influenced by lack of blinding
Incomplete outcome data (attrition bias) All outcomes	Low risk	All patients followed for two years
Selective reporting (reporting bias)	High risk	Not all review's pre‐specified outcomes have been reported. No data on numbers with FRNS
Other bias	Unclear risk	Insufficient information to assess whether an important risk of bias exists